Amphotericin B

[ CAS NO. ] 1397-89-3
[ Molecular Formula ] C47H73NO17
[ Molecular Weight ] 924.091
[ Melting Point ] >118°C (dec.)
[ Appearance ] Crystalline Yellow Solid
[ Usage ] Polypeptide antibiotic active against gram positive bacteria. Antifungal.
About Amphotericin B
Amphotericin B is a polyene antifungal antibiotic. It combines with sterols on the fungal cell membrane to change the permeability of the cell membrane, so that the important cell contents are lost and play an antifungal effect.
Amphotericin B has a broad-spectrum antibacterial spectrum and is similar to Cryptococcus, Blastomyces, Candida, Coccidioides, Histoplasma, Mucor, Aspergillus, Absidia, Endomys, and Schenk Sporium Bacteria, Aspergillus fumigatus, etc. have bacteriostatic effect.
With the exception of Mycoplasma, bacteria whose cells lack sterols cannot be affected by polyene antibiotics.
Amphotericin B, as a fungal inhibitor, is often used in the preparation of selective media.