Atrial Natriuretic Peptide

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[ CAS NO. ] 1366000-58-9
[ Molecular Formula ] C129H207N45O41S3
[ Molecular Weight ] 3140.53
[ Appearance ] White Powder
[ Purity ] ≥98.0%

[ Function ]
1. Vasodilation: ANP acts as a vasodilator, meaning it relaxes and widens blood vessels. This helps to reduce blood pressure by decreasing peripheral vascular resistance.
2. Natriuresis: ANP promotes the excretion of sodium by the kidneys. It inhibits sodium reabsorption in the renal tubules, leading to increased urinary sodium excretion. This mechanism helps to reduce blood volume and lower blood pressure.
3. Diuresis: ANP increases urine production by enhancing the filtration rate and reducing water reabsorption in the kidneys. This diuretic effect aids in eliminating excess fluid from the body.
4. Inhibition of renin-angiotensin-aldosterone system (RAAS): ANP counteracts the actions of the RAAS, a hormonal system that regulates blood pressure and fluid balance. It inhibits the release of renin, which leads to decreased production of angiotensin II and aldosterone. This inhibition helps to reduce vasoconstriction, water retention, and sodium reabsorption.
5. Cardiac effects: ANP has direct effects on the heart, including relaxation of cardiac muscle and inhibition of excessive cardiac hypertrophy (enlargement of the heart muscle). These effects contribute to maintaining normal heart function and preventing excessive strain on the heart.

About Atrial Natriuretic Peptide (ANP)
Atrial Natriuretic Peptide (ANP) is a hormone secreted by the atria of the heart. It plays a crucial role in regulating blood pressure, fluid balance, and electrolyte homeostasis in the body. ANP is released in response to increased stretching of the atrial walls, which typically occurs in conditions such as high blood pressure or fluid overload.
ANP levels are influenced by various factors, including blood volume, blood pressure, and hormonal regulation. Medical conditions such as heart failure, hypertension, and kidney disorders can impact ANP levels and its physiological effects.
ANP and other natriuretic peptides have been studied for their potential therapeutic applications, particularly in the management of heart failure and hypertension. Synthetic forms of ANP, such as nesiritide, have been used in certain clinical settings to help alleviate symptoms and improve cardiac function.