Cilengitide

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[ Sequence ] Cyclo(L-arginylglycyl-L-alpha-aspartyl-D-phenylalanyl-N-methyl-L-valyl
[ Cas NO. ]188968-51-6
[ Molecular Formula ] C27H40N8O7
[ Molecular Weight ] 588.65
[ Appearance ] White Powder
[ Purity ] 98%

About Cilengitide
Cilengitide is a synthetic peptidomimetic compound that has been investigated for its potential use in cancer treatment. It belongs to a class of drugs called integrin inhibitors.
Integrins are cell surface receptors that play a crucial role in cell adhesion and signaling. They are involved in various cellular processes, including cell migration, proliferation, and angiogenesis (the formation of new blood vessels). In cancer, integrins can promote tumor growth and metastasis by facilitating the interaction between cancer cells and the extracellular matrix.
Cilengitide specifically targets and inhibits integrins αvβ3 and αvβ5. By blocking these integrins, it is believed that Cilengitide may hinder the ability of cancer cells to interact with the extracellular matrix, potentially inhibiting tumor growth and metastasis.
Clinical trials have been conducted to evaluate the safety and efficacy of Cilengitide in various types of cancer, including glioblastoma (a type of brain cancer) and advanced solid tumors. However, the results have been mixed, and further research is needed to determine its precise role in cancer treatment.