Endomorphin-1

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[ CAS NO. ] 189388-22-5
[ Molecular Formula ] C34H38N6O5
[ Molecular Weight ] 610.715
[ Appearance ] White Powder
[ Purity ] 99%
[ Function ]
1. Analgesic effect:
It can inhibit the transmission of pain and enhance the body's ability to resist pain
2. Emotional regulation:
It can regulate the balance of emotion-related neurotransmitters and hormones, thereby improving negative emotions such as depression, anxiety, and fear, and enhancing positive emotions such as self-confidence, optimism, and happiness.
3. Affecting the reward circuit:
Endomorphin-1 participates in the transmission and processing of reward signals by binding to opioid receptors in the reward circuit.
4. Regulating the autonomic nervous system:
Endomorphin-1 is also involved in regulating the autonomic nervous system process, including the cardiovascular system, gastrointestinal system, etc.
5. Regulating immunity:
It affects the activity and function of immune cells, thereby regulating the intensity and direction of the immune response and enhancing the ability to resist infection and cancer.
About Endomorphin-1
Endomorphin-1 is mainly found in histaminergic neurons in the nucleus tractus solitarius, periventricular hypothalamus, and dorsomedial hypothalamus, and can regulate sedation and arousal behaviors. Its distribution in the brain is more extensive and dense than that of Endomorphin-2.
Endomorphin-1 is a highly selective, high-affinity μ-opioid receptor agonist that also has a high affinity for the kappa3 binding site. It plays an important regulatory role in the nervous system, especially in analgesia, mood regulation, influencing reward circuits, and regulating the autonomic nervous system.
As a neuropeptide with unique pharmacological properties, Endomorphin 1 not only acts on μ-opioid receptors with high selectivity, but also has a high affinity for the kappa3 binding site. Its analgesic properties provide new ideas and methods for pain management, and are expected to play an important role in future medical practice.
Endomorphin-1 is only for scientific research sharing and scientific research purposes, and shall not be used directly on humans, nor as medical advice.
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