Hyaluronic Acid(HA)

[ Specification ]  Distill Water 
[ Detection methods ]    HPLC
About Hyaluronic Acid(HA)
Hyaluronic acid(HA) is a straight chain macromolecular mucopolysaccharide composed Of repeat disaccharide units of glucuronic acid and N-acetylglucosamine. It widely consists in the extracellular space of human and animal tissue, vitreum, umbilical cord, skin joints synovia and cockscomb, etc.The commercial HA is commonly a sodium salt, called sodium hyaluronate, habitually called hyaluronic acid. Hyaluronic Acid is a new biological at home and abroad. Its molecular weight is from several ten thousand to several million. It¡¯s aqueous solution has outstanding moisture keeping ability, high viscoelasticity and lubricity. It is widely used in cosmetics, pharmacy and health and beauty food.
[ Grade ]
1. Cosmetic grade Hyaluronic Acid
Hyaluronic Acid is a natural biotic component, widely existing in skin and any other tissue. It has outstanding moisture keeping ability, thus called Natural Moisturing Factor (NMF) in the world. It is the best component used in cosmetics for moisture keeping in the nature.
When Hyaluronic Acid applied to the skin, macromolecular HA can form an air permeable thin layer and keep the skin smooth and moist, and protect the skin from bacteria, dust, and ultraviolet ray. With low molecular HA penetrating into corium, it will slightly enlarge blood capillaries, speed circulation of blood, improve intermediary metabolism and nourishment absorbing ability of skin, thus eliminating wrinkles, increasing skin's elasticity and delaying its aging. Hyaluronic Acid as well can further hyperplasia of epidermis cell, clean oxygen free radical, prevent and rehabilitate breach of skin. Its aqueous solution has very high viscosity which can make water become thicker. Creams made by means of emulsifying HA with oil is fine and homogeneous with stable emulsifiction.
Hyaluronic Acid is the best natural moisturizing component used in cosmetics. It has a good Compatibility
and can be added in various cosmetics such as cream, lotion. cosmetic water, essence, milk forfacewashing, liquid for bath, agentfor hair washing and protection£¬ mousse, lip stick. The incorporated quantities are about 0.05%-0.5%
COA of Hyaluronic Acid(cosmetic)
Appearance: White powder
Hyaluronic Acid: 98.7%
Gluconic acid: 40.7%
Molecular weight: 1.05 x 106 Dalton
PH: 7.1
Loss on drying: 9.1%
Particle size: 0.15-0.25 （mm）
Heavy metal: <20ppm
Arsenic: <2ppm
Heat remaining strong: 8.9%
Bacterial counts: <1000cfu/g
Mold and Yeast: <100cfu/g
Staphylococcus aureus: Can not be checkout Complies
Chlorop seu domonas: Can not be checkout
Shelf Life: Two Years
Storage condition: Shields light the airtight 0-8℃ preservation.
2. Pharmaceutical grade Hyaluronic Acid 
Hyaluronic Acid is the main component composing human intercellular substance, vitreum joints synovia, etc. It can retain water, keep intercellular space, accommodate osmotic pressure, lubricate and further rehabilitation of cells. In its aqueous solution, a mount of carboxyl and hydroxy in its molecular, which can form hydrogen bondings in molecule and between molecules, thus making it a powerful water keeping action. It can bond water over 400 multiple. In upper consistence, Hyaluronic Acid aqueous solution has high viscoelasticity because of its molecules form complex three reticula grades. As a main component of intercellular substance, HA directly concerns the transfer of exchange of electrolyte inside and outside cells, demonstrates the filter action of physical and molecule information. Macromolecule Hyaluronic Acid can prevent cells from move, hyperplasia, disintegration and engulfment, while low olecule HA has furtherance actions.
Hyaluronic Acid has peculiar physical and chemical property and biologic action, widely used in medicine. It can be used as a viscoelastic agent in artificial crystal planting in ocular surgery, as a fill agent in osteoarthritis, also as an agent in eye drops. It has good action of adhesion preventives in surgerical operations and healing cuts on skin. Compound of HA and other drug, the additive can make the action of drug delaying. With the development of medical technology. HA will be more widely used in medicine
3. Food grade Hyaluronic Acid
Hyaluronic Acid content is about 15g in a human body. It plays an important role in human biologic activity. With the decrease of HA content in skin, the water retaining ability of the skin is weakened, the skin looks coarse and wrinkle. The decrease of HA in other apparatus will lead to arthritis, arteriosclerosis, plus disorder and brain atrophy. All in all the decrease of HA in human body will lead to premature senility. 
Oral Hyaluronic Acid can increase HA content in human body, supply deficiency of HA. By digesting and absorbing HA, skin can be made moist, smooth, soft and rich spring. Oral HA can defer crowd senility; prevent arthritis, arteriosclerosis, plus disorder and brain atrophy. Oral HA can make one full of beans and be rich in youth energy.
COA of Hyaluronic Acid(food grade)
Appearance:  White powder
Assay: 95.7%
Molecular weight: 1.31 x 106
PH: 6.8
 drying: 9.4%
Protein: 0.09%
Nitrogen:  2.3%
Heavy metal: <20ppm
Bacterial counts: <1000cfu/g
Mold and Yeast:  <100cfu/g