Liraglutide

[ CAS NO. ] 204656-20-2
[ Molecular Formula ] C172H265N43O51
[ Molecular Weight ] 3751.262
[ Appearance ]  White Powder
[ Purity ] 99%

[ Function ]
1. Increase energy expenditure, reduce weight;
2. Reduce appetite, increase satiety, thereby reducing calorie intake, delay gastric emptying and gastrointestinal motility;
3. Promote the synthesis and secretion of insulin;
4. Inhibition of glucagon secretion;
5. Protect β cells and increase the number of β cells;
6. has the effect of lowering blood pressure;
7. Significantly lowers total cholesterol, triglycerides, and LDL levels
8. Cardiovascular protection;

About Liraglutide
Liraglutide is a human glucagon-like peptide-1 (GLP-1) analogue used in the treatment of diabetes. Liraglutide is a GLP-1 analog with 97% sequence homology to human GLP-1, which can bind and activate GLP-1 receptors. The GLP-1 receptor is the target of natural GLP-1, an endogenous incretin hormone that promotes glucose-dependent insulin secretion from pancreatic β cells. Unlike natural GLP-1, the pharmacokinetics and pharmacodynamics of liraglutide in humans are suitable for a once-daily dosing regimen.
The activity of liraglutide is mediated by its specific interaction with the GLP-1 receptor, resulting in an increase in cyclic adenosine monophosphate (cAMP). Liraglutide can stimulate insulin secretion in a glucose concentration-dependent manner, while reducing excessive glucagon secretion in a glucose concentration-dependent manner. Thus, when blood sugar rises, insulin secretion is stimulated while glucagon secretion is suppressed. In contrast, liraglutide can reduce insulin secretion during hypoglycemia without affecting glucagon secretion. The hypoglycemic mechanism of liraglutide also includes a slight prolongation of gastric emptying time. Liraglutide reduces body weight and body fat mass by reducing hunger and energy intake. Liraglutide can usually lower blood sugar, control diet and delay gastric emptying. It can play an auxiliary role in weight loss and relieve the symptoms of obesity.
Liraglutide can also suppress appetite, delay gastric emptying, reduce calorie intake, and help control weight. Liraglutide can not only effectively lower blood sugar and control body weight, but also improve blood pressure, blood lipids and other risk factors for coronary heart disease. It can also reduce body weight and has a protective effect on cardiovascular disease. Liraglutide is used to treat type 2 diabetes, especially obese patients with significant insulin resistance, which is beneficial to reduce insulin resistance and improve insulin sensitivity.