Neurotensin

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[ Cas NO. ] 39379-15-2
[ Molecular Formula ] C78H121N21O20
[ Molecular Weight ] 1672.92
[ Appearance ] White Powder
[ Purity ] 98%

[ Function ]
1. Reduce esophageal and small intestinal sphincter tension;
2. Inhibit small intestinal peristalsis;
3. Inhibit gastric acid secretion and delay gastric emptying;
4. Inhibit small intestinal mucosal blood flow and reduce small intestinal secretion;
5. Stimulate pancreatic secretion and increase the intensity of CCK and secretin response to pancreatic exocrine secretion;
6. Contracts the colon to defecate, which is the main mediating factor in the gastro-colonic reflex;
7. Relax the gallbladder;
8. Effects on the central nervous system: NT is closely related to dopamine and other transmitter systems, and plays an important role in the pathogenesis of neuropsychiatric diseases related to dopamine circuits, such as schizophrenia, Parkinson's disease and drug abuse;

About Neurotensin
Neurotensin is a neuropeptide that plays a role in the central nervous system and the gastrointestinal tract. It is composed of 13 amino acids and is produced in various regions of the body, including the brain and the gastrointestinal tract.
In the central nervous system, neurotensin acts as a neurotransmitter and neuromodulator, influencing a wide range of physiological functions. It is involved in the regulation of pain perception, body temperature, blood pressure, locomotor activity, and gut motility. Neurotensin also interacts with dopamine, serotonin, and other neurotransmitters, affecting their release and activity.
In the gastrointestinal tract, neurotensin acts as a hormone and is released by specialized cells in the small intestine in response to the presence of fat in the digestive system. It regulates various aspects of digestion and absorption, including the release of pancreatic enzymes, the contraction of smooth muscles in the intestine, and the absorption of nutrients.
Research has also suggested that neurotensin may have implications in other areas of health. It has been studied for its potential role in cancer progression, as neurotensin receptors are found in high levels in certain types of cancer cells. Additionally, neurotensin has been investigated for its involvement in psychiatric disorders, such as schizophrenia and drug addiction.