Oleanolic Acid

[ Other Name ] Oleanic Acid
[ CAS No. ] 508-02-1
[ Molecular Formula ] C30H48O3
[ Molecular Weight ] 456.711
[ Appearance ] White Powder
[ Purity ]  60% 70% 98%
[ Function ] 
1. Alleviate liver injury: Oleanolic acid is a pentacyclic triterpenoid compound, which has obvious protective effect on acute and chronic liver injury in rats caused by carbon tetrachloride.
2. Reduce the activity of plasma alanine aminotransferase: Oleanolic acid has obvious effect on reducing the enzyme in animals with acute and chronic hepatitis and liver cirrhosis.
3. Serum r-globulin was decreased, and was consistent with a reduction in liver-related inflammatory responses observed by histology.
4. Promote the regeneration of hepatocytes: Oleanolic acid can significantly increase the number of mitotic phases in the residual liver of rats, and the regeneration degree is higher than that of the control group, suggesting that it has the effect of promoting cell regeneration.
5. Reducing the level of tyrosine in brain homogenate of liver cirrhosis rats: Since the level of tyrosine in brain homogenate is significantly reduced, it can inhibit the generation of pseudo-neurotransmitters, so it is beneficial to the prevention and treatment of hepatic encephalopathy.
6. Inhibition of hepatic fibrosis: In hepatic fibrotic rats treated with oleanolic acid, hepatic fibrosis was severe and significantly alleviated, and the content of hepatic collagen decreased, suggesting that it has the effect of preventing and treating liver cirrhosis.
7. Oleanolic acid has obvious inhibitory effects on mouse mononuclear phagocyte system, macrophage phagocytic function and experimental arthritis, but has effects on heterosexual humoral immune function and antigen-binding cells. Enhance immunity and inhibit the growth of S180 tumor line.
8. It has a protective effect on chromosomal damage, has a preventive effect on experimental atherosclerosis, and can also correct protein metabolism disorders.
About Oleanolic Acid
Oleanolic acid is a kind of pentacyclic triterpenoid compound which is isolated and extracted from the fruit of the whole herb of the gentian plant sagebrush or the fruit of Ligustrum lucidum. It exists in free form and glycoside in poly In plants, it has become a commonly used hepatoprotective drug in clinical practice. Oleanolic acid has the functions of anti-inflammatory, sedative, cardiotonic, diuretic, hypolipidemic, hypoglycemic, protecting liver and lowering enzymes, enhancing immunity and inhibiting the growth of S180 tumor strain.
Oleanolic acid mainly has the functions of protecting the liver and reducing enzymes, promoting the regeneration of liver cells, anti-inflammatory, strengthening the heart, diuretic, anti-tumor, etc. It is an active ingredient in the development of drugs such as liver disease and hypoglycemia.