Pentagastrin

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[ CAS NO. ] 5534-95-2
[ Molecular Formula ] C37H49N7O9S
[ Molecular Weight ] 767.90
[ Appearance ] White Powder
[ Purity ] >98.0%

[ Function ]
Can promote the secretion of gastric acid, pepsin and intrinsic factor

About Pentagastrin
Pentagastrin is a synthetic peptide that acts as a powerful stimulant of gastric acid secretion. It is derived from the gastrin hormone, which is naturally produced in the stomach and plays a role in regulating gastric acid production and other digestive processes. Pentagastrin is used in medical settings for diagnostic purposes, particularly in tests that assess the function of the stomach.
When administered, pentagastrin binds to specific receptors on the surface of cells in the stomach lining, known as parietal cells. This binding triggers a signaling cascade that leads to an increase in the production and secretion of gastric acid. This effect can be measured by analyzing the gastric acid output or pH levels in the stomach.
Pentagastrin stimulation tests are commonly used to evaluate patients with suspected abnormalities in gastric acid secretion or to assess the effectiveness of treatments for certain gastrointestinal conditions. For example, the pentagastrin stimulation test may be performed to diagnose Zollinger-Ellison syndrome, a rare disorder characterized by excessive gastrin production and gastric acid hypersecretion. The test can also be used to evaluate gastric acid secretion before and after gastric surgery.