PNC-27

Buy PNC-27 Peptide at Wholesale Price. High Quality. Low Price. Inquiry Now!
Anti-cancer Peptide PNC-27 Price & Cost; Get PNC-27 For Sale From Manufacturer/Supplier, Benefits - Bolise.

[ Molecular Formula ] C188H293N53O44S
[ Molecular Weight ] 4031.7
[ Appearance ] White Powder
[ Purity ] 99%
[ Source ] synthetic

[ Function ]
1. Anti-cancer activity;
2. Tumor suppression;
3. Cancer cell cytotoxicity;

About PNC-27
PNC-27, an anticancer peptide, containing an HDM-2 binding domain corresponding to p53 residues 12-26 and a transmembrane penetrating domain, has been found to kill cancer cells but not normal cells by inducing membrane lysis. The 3D structure of the p53 residue of PNC-27 directly overlaps the structure of the same residue that binds HDM-2, suggesting that this peptide may target HDM-2 in the cell membrane. The researchers found significant levels of HDM-2 in the cell membranes of a variety of cancer cells but not in some untransformed cell lines. In colocalization experiments, PNC-27 peptide bound to cell membrane-bound HDM-2. The researchers used a membrane localization signal to transfect a plasmid expressing full-length HDM-2 into PNC-27-insensitive untransformed MCF-10-2A cells and found that these cells expressed full-length HDM-2 on their cell surface. cells versus PNC-27. We concluded that PNC-27 targets HDM-2 in cancer cell membranes, allowing it to selectively induce membrane lysis in these cells.
PNC-27 peptide is a non-toxic protein molecule. Clinically, PNC-27 can attach to cancer cells and find specific receptors, causing cancer cells to die.PNC-27 peptide has anti-tumor activity and can be used in the research of acute myeloid leukemia.