Protamine

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[ Appearance ] White Powder
[ Purity ] 99%

[ Function ]
1. Compact and condense the DNA within the sperm nucleus;
2. Help stabilize the chromatin structure in the sperm nucleus;
3. Protection of DNA, can bind to negatively charged nucleic acids (like RNA and DNA);
4. Prevent excessive bleeding by reversing heparin's effects;
5. May exhibit antimicrobial properties, making it a candidate for use in formulations aimed at preventing infections;
6. Can facilitate the uptake of various compounds into cells, enhancing the effectiveness of certain drugs by improving their bioavailability;
7. Used to create protamine zinc insulin (PZI), which is a long-acting insulin preparation;

About Protamine
Protamine is a type of protein that is rich in arginine and is primarily derived from fish sperm, particularly from species like salmon and sturgeon. Protamine is a low-molecular-weight protein, and its structure allows it to interact strongly with negatively charged molecules like heparin.It is highly soluble in water, which is important for its use in medical applications.
Protamine is commonly used in clinical settings to reverse the effects of heparin, an anticoagulant medication. It binds to heparin and neutralizes its activity, making it crucial during surgical procedures where blood clotting needs to be controlled.
It can be used in the formulation of certain drugs, such as insulin, to modify the absorption and prolong the drug's effect.
Protamine is also used in molecular biology, particularly in studies related to gene delivery and as a carrier for genetic material.
Protamine plays a significant role in medicine, particularly in surgery and drug formulations. Its ability to reverse anticoagulation makes it a valuable tool in managing patients undergoing procedures that require precise control of blood clotting.