Protirelin

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[ CAS NO. ] 24305-27-9
[ Molecular Formula ] C16H21N5O5
[ Molecular Weight ] 363.368
[ Appearance ] White Powder
[ Purity ] 99%

[ Function ]
1. Protirelin stimulates the release of thyroid-stimulating hormone (TSH) from the pituitary gland, which in turn promotes the production and release of thyroid hormones (T3 and T4) from the thyroid gland. 
2. By influencing thyroid hormone levels, protirelin plays a significant role in metabolic processes, including energy expenditure and thermogenesis.
3. Protirelin may have effects on neurotransmitter systems, influencing emotional responses and stress levels.
4. Protirelin can be involved in the body’s response to stress, coordinating the release of other hormones that help manage stress reactions.
5. Protirelin can affect the release of other hormones, including prolactin, which is involved in lactation and reproductive functions.

About Protirelin
Protirelin, also known as thyrotropin-releasing hormone (TRH), is a tripeptide hormone that plays a crucial role in the regulation of the hypothalamic-pituitary-thyroid axis. 
Protirelin is primarily recognized for its role in stimulating the release of thyroid-stimulating hormone (TSH) from the anterior pituitary gland. TSH, in turn, stimulates the thyroid gland to produce and release thyroid hormones, which are essential for regulating metabolism, growth, and other bodily functions.
Regulation of the Hypothalamic-Pituitary-Thyroid Axis: Protirelin acts at the hypothalamus to stimulate the release of TSH, which then acts on the thyroid gland to regulate the production of thyroid hormones, including thyroxine (T4) and triiodothyronine (T3).
Protirelin/TRH is sometimes used in medical settings as a diagnostic tool to assess the function of the hypothalamic-pituitary-thyroid axis. For example, it can be used in TRH stimulation tests to evaluate the response of the pituitary gland to TRH stimulation.