Saralasin

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[ Sequence ] Sar-Arg-Val-Tyr-Val-His-Pro-Ala
[ CAS NO. ] 34273-10-4
[ Molecular Formula ] C42H65N13O10
[ Molecular Weight ] 912.05
[ Appearance ] White Powder
[ Purity ] 98%

[ Function ]
It is a highly specific competitive inhibitor of angiotensin II and is used in the diagnosis of hypertension.

About Saralasin
Saralasin, also known as saralasin tetratricopeptide repeat domain peptide (TPR), is a synthetic peptide that was originally developed as an antihypertensive agent. It is derived from angiotensin II, a hormone involved in regulating blood pressure.
Saralasin acts as a competitive antagonist of angiotensin II receptors, specifically the angiotensin type 1 receptor (AT1 receptor). By binding to and blocking the AT1 receptor, saralasin prevents the binding of angiotensin II and inhibits its physiological effects.
The main use of saralasin is in research and experimental settings to study the renin-angiotensin-aldosterone system (RAAS) and its role in blood pressure regulation. It has been used to investigate the effects of blocking angiotensin receptors and to explore the mechanisms underlying hypertension.