Sorafenib Tosylate

[ CAS No. ] 475207-59-1
[ Molecular Weight ] 637.03
[ Molecular Formula ] C21H16ClF3N4O3.C7H8SO3  
[ Appearance ] White to off-white crystalline powder
[ Density ] 1.454 g/cm3
[ Boiling Point ] 523.3 °C at 760 mmHg
[ Flash Point ] 270.3 °C
About Sorafenib Tosylate
Sorafenib tosylate is a new multi-targeted anti-tumor drug developed by Bayer AG in Germany that can act on both tumor cells and tumor blood vessels. It has a dual antitumor effect: it can directly inhibit the proliferation of tumor cells by blocking the cell signaling pathway mediated by RAF / MEK / ERK, and can also inhibit the growth of tumor cells by inhibiting VEGF and platelet-derived growth factor (PDGF) receptors Blocking the formation of neovascularization, indirectly inhibiting the growth of tumor cells.
Sorafenib tosylate is used for the treatment of primary kidney cancer, advanced primary liver cancer, and radioactive iodine resistant advanced thyroid carcinoma.