SS-31 Peptide

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[ Other Name ] Elamipretide; MTP-131
[ Cas NO. ] 736992-21-5
[ Molecular Formula ] C32H49N9O5
[ Molecular Weight ] 639.802
[ Appearance ] White Powder
[ Purity ] 98%

[ Function ]
1. Reduce cellular stress;
2. It can improve left ventricular and mitochondrial function, repair mitochondrial efficiency and reduce cell stress to 3. Promote the remodeling of heart cells;
4. Promote the health of mitochondria, the power source of cells;
5. Improve heart function;
6. Protect the kidneys;
7. It has therapeutic effect on ischemia-reperfusion injury, neurodegenerative diseases, heart failure, muscle aging and other diseases related to free radicals;
8. Can reduce mitochondrial dysfunction and oxidative damage in human trabecular meshwork cells;

About SS-31 Peptide
SS-31 peptide is a new mitochondria-targeting small molecule peptide that can be used as a mitochondrial stabilizer to restore damaged mitochondrial function. It improves left ventricular and mitochondrial function. SS-31 peptide reduces mitochondrial dysfunction and oxidative damage in human trabecular meshwork cells. It protects iHTM and GTM(3) cells from H2O2-induced sustained oxidative stress. Phase II clinical trials for the treatment of chronic heart failure and mitochondrial myopathies are ongoing.
SS-31 peptide is an opioid peptide derived from dermorphin. It has a strong analgesic effect and good ability to pass through cell membranes. After in-depth mechanism research, the mitochondria-targeted antioxidant peptide SS-31 (H-D -Arg-Dmt-Lys-Phe-NH2). SS-31 peptide has a therapeutic effect on ischemia-reperfusion injury, neurodegenerative diseases, heart failure, muscle aging and other diseases related to free radicals. SS-31 peptide is a molecule that targets mitochondria. It interacts with cardiolipin to reactivate ischemic mitochondria. At the same time, SS-31 is also a cell-penetrating peptide.
MTP-131; D-Arg-DMT-Lys-Phe-NH2; where DMT is 2,6-dimethyl-L-Tyr) is a drug with the potential to treat ischemia-reperfusion injury (e.g., cardiac ischemia-reperfusion injury ) and myocardial infarction. Mitochondria-targeting compounds with therapeutic potential. Analogs of such compounds may have improved therapeutic profiles, including improved metabolic properties, selectivity, or potency.
SS-31 peptide is a small molecule polypeptide composed of four amino acids. Elamipretide targets the inner mitochondrial membrane in vivo and can prevent oxidative damage to nerve cells and other cell types; prevent mitochondrial depolarization and reduce pancreatic islet cell apoptosis , increase islet cell production and improve post-transplant function. The drug using Elamipretide as the main raw material has entered the third phase of clinical trials.