Trimethoprim

[ Synonyms ]  Proloprim; Trimpex; Bactramin
[ CAS NO. ] 738-70-5  
[ Molecular Formula ]  C14H18N4O3
[ Molecular weight ]  290.323
[ Appearance ]  White Powder
[ Purity ]  99%min
[ Main Functions ] 
1. It can be used as a synergistic antimicrobial drugs; it can also be used for treating bacterial infections and coccidiosis in poultry. 
2. It is a novel orally administrated broad-spectrum antibiotics. It has a similar antibacterial spectrum with sulfa drugs but with a stronger potency. It is effective in treating a variety of Gram positive and negative bacteria. Since the bacteria is easy to evolve drug resistance to this product, it is not suitable to be used alone as an antimicrobial drug. The combination between trimethoprim and sulfa drugs can enhance the antibacterial activity by several times to several dozens of times. The product is mainly used for being as the synergistic drugs for sulfonamide drugs with a general ratio of 1: 5 for usage. It can also be used as a veterinary drug for treatment of avian sepsis caused by Escherichia coli, salmonellosis, fowl typhoid, cholera, and respiratory system secondary bacterial infections. It can also be used for the treatment of coccidiosis.  
[ Application ]
Used as antibacterial synergistic drugs; treat respiratory tract infections, urinary tract infections and intestinal infections when being used alone.
About Trimethoprim
Trimethoprim is a lipophilic weakly basic pyrimethamine bacteriostatic agent, white or off-white crystalline powder at room temperature, odorless, bitter, slightly soluble in chloroform, slightly soluble in ethanol or acetone, almost insoluble in water, easy to use in glacial acetic acid Dissolved. The antibacterial spectrum is similar to that of sulfa drugs, but it has strong antibacterial effect. It is effective against Escherichia coli, Proteus mirabilis, Klebsiella pneumoniae, Staphylococcus aureus, and various Gram-positive and negative bacteria, but it is not effective against Pseudomonas aeruginosa infection. Often less than 10mg / L, single use is easy to cause bacterial resistance, it is generally not used alone, mainly with sulfa drugs constitute a compound preparation, clinically used to treat urinary tract infections, intestinal infections, respiratory tract infections, dysentery, enteritis , typhoid, meningitis, otitis media, meningitis, sepsis and soft tissue infections. The efficacy of typhoid fever and paratyphoid fever is not lower than that of ampicillin, and it can also be combined with long-acting sulfa drugs for the prevention and treatment of drug-resistant falciparum malaria.